RADIATION-INDUCED SARCOMAS: A SURGICAL CHALLENGE

Authors

  • Paula Ferreira Pinto Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
  • José Carlos Pereira Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
  • Ana Margarida Correia Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0003-0112-7401
  • Catarina Baía Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0002-0696-5212
  • Mariana Marques Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
  • José Silva Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
  • Pedro Martins Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
  • Lúcio Lara Santos Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal; Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0002-0521-5655
  • Joaquim Abreu de Sousa Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0002-4988-6987

DOI:

https://doi.org/10.34635/rpc.984

Keywords:

MPNST, radiotherapy treatment, radiation-induced sarcomas, multimodality treatment

Abstract

Malignant peripheral nerve sheath tumors (MPNST) are uncommon, biologically challenging soft tissue sarcomas. The definitive treatment of these tumors is extremely challenging. In 50% of cases, these tumors are associated with type I neurofibromatosis, but in some cases, the cause can be previous treatment with radiotherapy. The present article pretends to report a clinical case of a radiation-induced MPNST submitted to surgical treatment.

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References

1. Bishop AJ, Zagars GK, Torres KE, Bird JE, Feig BW, Guadagnolo BA. Malignant Peripheral Nerve Sheath Tumors: A Single Institution’s Experience Using Combined Surgery and Radiation Therapy. Am J Clin Oncol. 2018 May;41(5):465-470. doi: 10.1097/COC.0000000000000303.

2. Prudner BC, Ball T, Rathore R, Hirbe AC. Diagnosis and management of malignant peripheral nerve sheath tumors: Current practice and future perspectives. Neurooncol Adv. 2019 Nov 14;2(Suppl 1):i40-i49. doi: 10.1093/noajnl/vdz047.

3. Miao R, Wang H, Jacobson A, Lietz AP, Choy E, Raskin KA, Schwab JH, Deshpande V, Nielsen GP, DeLaney TF, Cote GM, Hornicek FJ, Chen YE. Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST. Radiother Oncol. 2019 Aug;137:61-70. doi: 10.1016/j.radonc.2019.03.015.

4. Goldblum J, Folpe A, Weiss S (2021). Malignant Peripheral Nerve Sheath Tumors in Euzinger and Weiss’s Soft Tissue Tumors, 7th edition: Elsevier 27: 959-990

5. Farid M, Demicco EG, Garcia R, Ahn L, Merola PR, Cioffi A, Maki RG. Malignant peripheral nerve sheath tumors. Oncologist. 2014 Feb;19(2):193-201. doi: 10.1634/theoncologist.2013-0328.

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Published

2024-01-11

Issue

No. 56 (2023): December

Section

Clinical Case

License

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