RADIATION-INDUCED SARCOMAS: A SURGICAL CHALLENGE

Paula Ferreira Pinto; José Carlos Pereira; Ana Margarida Correia; Catarina Baía; Mariana Marques; José Silva; Pedro Martins; Lúcio Lara Santos; Joaquim Abreu de Sousa

doi:10.34635/rpc.984

Paula Ferreira Pinto Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
José Carlos Pereira Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
Ana Margarida Correia Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0003-0112-7401
Catarina Baía Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0002-0696-5212
Mariana Marques Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
José Silva Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
Pedro Martins Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal
Lúcio Lara Santos Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal; Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0002-0521-5655
Joaquim Abreu de Sousa Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal http://orcid.org/0000-0002-4988-6987

Abstract

Malignant peripheral nerve sheath tumors (MPNST) are uncommon, biologically challenging soft tissue sarcomas. The definitive treatment of these tumors is extremely challenging. In 50% of cases, these tumors are associated with type I neurofibromatosis, but in some cases, the cause can be previous treatment with radiotherapy. The present article pretends to report a clinical case of a radiation-induced MPNST submitted to surgical treatment.

Downloads

Download data is not yet available.

References

1. Bishop AJ, Zagars GK, Torres KE, Bird JE, Feig BW, Guadagnolo BA. Malignant Peripheral Nerve Sheath Tumors: A Single Institution’s Experience Using Combined Surgery and Radiation Therapy. Am J Clin Oncol. 2018 May;41(5):465-470. doi: 10.1097/COC.0000000000000303.

2. Prudner BC, Ball T, Rathore R, Hirbe AC. Diagnosis and management of malignant peripheral nerve sheath tumors: Current practice and future perspectives. Neurooncol Adv. 2019 Nov 14;2(Suppl 1):i40-i49. doi: 10.1093/noajnl/vdz047.

3. Miao R, Wang H, Jacobson A, Lietz AP, Choy E, Raskin KA, Schwab JH, Deshpande V, Nielsen GP, DeLaney TF, Cote GM, Hornicek FJ, Chen YE. Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST. Radiother Oncol. 2019 Aug;137:61-70. doi: 10.1016/j.radonc.2019.03.015.

4. Goldblum J, Folpe A, Weiss S (2021). Malignant Peripheral Nerve Sheath Tumors in Euzinger and Weiss’s Soft Tissue Tumors, 7th edition: Elsevier 27: 959-990

5. Farid M, Demicco EG, Garcia R, Ahn L, Merola PR, Cioffi A, Maki RG. Malignant peripheral nerve sheath tumors. Oncologist. 2014 Feb;19(2):193-201. doi: 10.1634/theoncologist.2013-0328.