CANCRO COLORETAL ENTRE A APLICAÇÃO CLÍNICA E A INVESTIGAÇÃO TRANSLACIONAL – ONDE ESTAMOS E O QUE PODE SER MELHORADO?

Resumo

O Cancro colorectal é o segundo tipo de cancro mais mortal. A heterogeneidade celular deste tumor tem impacto no diagnóstico, no tratamento e prognóstico. Este tumor maligno é curável quando diagnosticado em fase inicial, e a sobrevivencia é longa (90% aos 5 anos) quando diagnosticado no estágio I, mas a ausência de sintomas torna por vezes o diagnóstico difícil. Assim, o conhecimento da biologia tumoral, da genética e a expressão de biomarcadores tumorais específicos deste tumor malign são fundamentais para protocolos de detecção mais precoces. Estudos paralelos demonstraram o papel determinante das modificações pós-transcripcionais na carcinogénese e progressão do canco colorectal. A presente revisão tem como objetivo resumir e associar os diferentes aspectos biológicos envolvidos nos distintos perfis desta neoplasia maligna, importantes na decisão médica. Pretendemos dar uma visão o que os investigadores já sabem e o que é necessário ainda fazer e conhecer. 

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Publicado
2020-09-30
Como Citar
ZOPPI, Roberta et al. CANCRO COLORETAL ENTRE A APLICAÇÃO CLÍNICA E A INVESTIGAÇÃO TRANSLACIONAL – ONDE ESTAMOS E O QUE PODE SER MELHORADO?. Revista Portuguesa de Cirurgia, [S.l.], n. 48, p. 65-80, sep. 2020. ISSN 2183-1165. Disponível em: <https://revista.spcir.com/index.php/spcir/article/view/816>. Acesso em: 26 oct. 2020. doi: https://doi.org/10.34635/rpc.816.
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