LATE CUTANEOUS METASTASES FROM GASTRIC CARCINOMA

A Case Report

Authors

  • José Pinto Interno de Formação Específica, Centro Hospitalar Tondela-Viseu, Portugal http://orcid.org/0000-0002-1868-360X
  • Liliana Duarte Assistente Hospitalar, Centro Hospitalar Tondela-Viseu, Portugal
  • Marta Ferreira Assistente Hospitalar, Centro Hospitalar Tondela-Viseu, Portugal
  • Rosa Simão Assistente Graduada, Centro Hospitalar Tondela-Viseu, Portugal
  • Conceição Marques Assistente Graduada, Centro Hospitalar Tondela-Viseu, Portugal
  • Luís Filipe Pinheiro Assistente Graduado Sénior, Centro Hospitalar Tondela-Viseu, Portugal
  • Carlos Casimiro Director de Serviço, Centro Hospitalar Tondela-Viseu, Portugal

DOI:

https://doi.org/10.34635/rpc.822

Keywords:

Gastric, Carcinoma, Cutaneous, Metastases

Abstract

Cutaneous metastases from primary gastric carcinoma are uncommon, generally occur late in the course of the disease and have a poor prognosis. We report a long-term survival of a patient with cutaneous metastases from a gastric carcinoma. A 56-year-old patient, previously diagnosed with a poorly differentiated signet-ring cell gastric carcinoma staged as ypT3N3aM0, who underwent total gastrectomy with Roux-en-y reconstruction and extended lymphadenectomy (D2) 7 years prior, with no evidence of disease recurrence. At presentation, physical examination revealed firm erythematous nodular lesions in the face and neck, and palpable adenopathy in the left axilla. Laboratory workup showed mild anemia, and the tumour markers were negative. The staging PET-CT scan revealed left axillary and right inguinal lymph nodes metastases. The patient underwent a complete resection of the facial lesion, and the histopathology of the specimen was compatible with cutaneous metastases of signet-ring cell gastric adenocarcinoma. The patient received postoperative chemotherapy with clinical remission at 24 months follow-up. This case report of long-term survival in a metastatic gastric carcinoma emphasizes that although cutaneous metastases are rare, they should be considered when assessing suspicious lesions in patients with a history of gastric carcinoma.

Downloads

Download data is not yet available.

References

1. Koyama R, Maeda Y. Late Cutaneous Metastases Originating from Gastric Cancer with Synchronous Metastases. 2019;0804:95-101. doi:10.1159/000497099.

2. Mbbs SCH, Chen G, Wu C, Chai C, Ms WC, Lan CE. Rates of cutaneous metastases from different internal malignancies: Experience from a Taiwanese medical center. J. Am. Dermatology 2009;60(3):379-387. doi:10.1016/j.jaad.2008.10.007.

3. Murugasu R. Skin metastases in carcinoma of the stomach. 1972;(1968).

4. Früh M. Resection of Skin Metastases from Gastric Carcinoma with Long-Term Follow-Up : An Unusual Clinical Presentation. 2005:2004-2006. doi:10.1159/000082266.

5. Cesaretti M, Malerba M, Basso V, Boccardo C. Cutaneous Metastases From Primary Gastric Cancer: A Case Report and Review of the Literature. Cutis 2014;93(APRIL):9-13.

6. Abbasi F, Abbasi A, Mahmodlou R, Mehdipour E. Cutaneous Metastases of Gastric Carcinoma : A Rare Case with Unusual Presentation Site. 2018:2018-2020. doi:10.4103/ijdpdd.ijdpdd.

7. Schwartz RA. Cutaneous metastatic disease. 1995;33:161-185.

8. Liu F, Zhang M, Yan WL, Sang H. Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy *. 1997;(Figure 1):46-50.

9. Foo KF, Tao M, Tan EH. Gastric Carcinoma Presenting with Cellulitis-Like Cutaneous Metastases. 2002;43(1):37-38.

10. Hashimoto K, Nelson G. Cutaneous metastases of gastric signet ring cell carcinoma masquerading as allergic contact Reduced growth of beard as the only diagnostic sign in a patient with macroprolactinoma. 2007:2006-2007. doi:10.1111/j.1468-3083.2006.01809.x.

11. Lee HJ, Song I, Yun H, et al. CXC chemokines and chemokine receptors in gastric cancer : From basic findings towards therapeutic targeting. 2014;20(7):1681-1693. doi:10.3748/wjg.v20.i7.1681.

12. Neagu M, Constantin C, Caruntu C, Dumitru C, Surcel M, Zurac S. Inflammation : A key process in skin tumorigenesis ( Review). 2019:4068-4084.

13. Sr JM. Chemokine receptor expression in non-melanoma skin cancer. 2008:623-629. doi:10.1111/j.1600-0560.2007.00879.x.

14. Namikawa T, Munekage ERI, Munekage M, Maeda H. Subcutaneous metastases arising from gastric cancer : A case report. 2017:515-516. doi:10.3892/mco.2017.1175.

15. Menghani S V, Barbosa A, Sagerman P, et al. (January 27, 2020) Gastric Cardia Adenocarcinoma with Metastases to the Scalp: A Case Report. Cureus 12(1): e6781.

16. Song Z, Wu Y, Yang J, Yang D, Fang X. Progress in the treatment of advanced gastric cancer. Tumour Biol. 2017 Jul;39(7):1010428317714626. doi: 10.1177/1010428317714626.

Downloads

Published

2022-03-13

Issue

Section

Clinical Case

Most read articles by the same author(s)