Intrahepatic Colangiocarcinoma

  • Francisco Castro Sousa Professor Catedrático de Cirurgia da Faculdade de Medicina da Universidade de Coimbra, Director de Serviço, Serviço de Cirurgia A - HUC – Centro Hospitalar e Universitário de Coimbra - Portugal
  • Edgar Tavares da Silva Interno do Internato da Especialidade de Urologia, Serviço de Cirurgia A - HUC – Centro Hospitalar e Universitário de Coimbra - Portugal
  • José Guilherme Tralhão Prof. Auxiliar com Agregação da Faculdade de Medicina da Universidade de Coimbra, Assistente Hospitalar de Cirurgia, Serviço de Cirurgia A - HUC – Centro Hospitalar e Universitário de Coimbra - Portugal
  • Beatriz Costa Assistente Convidada da Clínica Universitária de Cirurgia III, Assistente Graduada de Cirurgia, Serviço de Cirurgia A - HUC – Centro Hospitalar e Universitário de Coimbra - Portugal
  • Mónica Martins Assistente Hospitalar de Cirurgia, Serviço de Cirurgia A - HUC – Centro Hospitalar e Universitário de Coimbra - Portugal
  • Marco Serôdio Interno da Especialidade de Cirurgia Geral, Serviço de Cirurgia A - HUC – Centro Hospitalar e Universitário de Coimbra - Portugal
  • Ricardo Martins Interno da Especialidade de Cirurgia Geral, Serviço de Cirurgia A - HUC – Centro Hospitalar e Universitário de Coimbra - Portugal

Abstract

Introduction: intrahepatic cholangiocarcinoma (CCIhp) is a rare malignant tumor usually diagnosed at an advanced stage. This study intends to assess the treatment results of CCIhp and to define the prognostic factors of survival in treated at our department. Material and methods: Twenty-one patients undergoing treatment for CCIhp in recent years, of which eleven were operated with curative intent: four left hepatectomies, two left hepatectomies extended to segments V and VIII, two right hepatectomies, two bisegmentectomies and a trisegmentectomy. Results: Perioperative mortality was 0%, postoperative (three months) 6%. The cumulative survival rates at 5 years were 14% in the total population, 26% in patients who underwent curative surgery and 26% for the disease free cumulative survival. There was recurrence in five patients, which was diagnosed at 1.09 ± 0.82 years (range: 0.24 to 2.08). Factors that influenced the overall survival of patients were surgery with curative intent (p=0.028), presence of vascular invasion (p=0.002) and alkaline phosphatase at diagnosis (p=0.044). Among patients operated with curative intentions, the presence of vascular invasion influenced overall survival (p=0.025) and disease-free survival (p=0.002). Conclusions: Surgical treatment with curative intent was the only one who enhanced survival of patients with CCIhp. However, as the diagnosis is usualy late, only a small percentage of these patients may benefit from this treatment.

Keywords: Intrahepatic cholangiocarcinoma; prognostic factors; treatment. 

Downloads

Download data is not yet available.
Published
2012-12-31
How to Cite
SOUSA, Francisco Castro et al. Intrahepatic Colangiocarcinoma. Revista Portuguesa de Cirurgia, [S.l.], n. 23, p. 33-42, dec. 2012. ISSN 2183-1165. Available at: <https://revista.spcir.com/index.php/spcir/article/view/25>. Date accessed: 21 may 2024.
Section
Original Papers