AS CONCENTRAÇÕES SÉRICAS DE IMUNOGLOBULINA NÃO SE CORRELACIONAM COM APENDICITE AGUDA

Resumo

As imunoglobulinas são um componente central da imunidade humoral e as suas concentrações séricas são determinadas por rotina na prática clínica, pois fornecem informações importantes sobre o estado imunológico humoral. Num estudo prospetivo de centro único, avaliámos as concentrações séricas de IgA, IgE, IgG e IgM em doentes com apendicite aguda confirmada histologicamente (grupo de estudo, N=54) e comparámos com o grupo controle (N=69), doentes submetidos a apendicectomia, mas com achados histológicos normais, doentes submetidos a cirurgia de ambulatório e voluntários saudáveis. As concentrações séricas de imunoglobulinas foram normais em todos os casos, exceto para IgE, que estava elevada tanto no grupo estudo (20%) quanto no grupo controle (21%) (p= 0,609). Esses valores estão em boa concordância com a prevalência de alergias na população geral. O nosso estudo é o primeiro a abordar especificamente a resposta imune humoral de imunoglobulinas na apendicite aguda na literatura inglesa. Demonstrámos que a apendicite aguda não provoca uma resposta imune humoral específica.

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Biografias Autor

Luís Moita, Innate Immunity and Inflammation Lab – Instituto Gulbenkian de Ciência, Oeiras, Portugal; Instituto de Histologia e Biologia do Desenvolvimento, Faculdade Medicina, Universidade Lisboa, Portugal
 
Paulo Costa, Serviço Cirurgia Geral, Hospital Garcia de Orta, Almada, Portugal; Faculdade Medicina, Universidade Lisboa, Portugal
 

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Publicado
2022-12-09
Como Citar
CARVALHO, Nuno et al. AS CONCENTRAÇÕES SÉRICAS DE IMUNOGLOBULINA NÃO SE CORRELACIONAM COM APENDICITE AGUDA. Revista Portuguesa de Cirurgia, [S.l.], n. 53, p. 37-45, dec. 2022. ISSN 2183-1165. Disponível em: <https://revista.spcir.com/index.php/spcir/article/view/970>. Acesso em: 08 feb. 2023. doi: https://doi.org/10.34635/rpc.970.
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