Carcinoma da Paratiróide

  • Ana Luísa Castro Barbosa Faculdade de Medicina da Universidade do Porto
  • João Capela Costa Unidade de Cirurgia Endócrina e Cervical do Serviço de Cirurgia Geral do Hospital São João

Resumo

O carcinoma da paratiroide (CP) é um tumor endócrino muito raro, correspondendo a menos de 1% dos casos de hiperparatiroidismo primário (HPT-P). Tal como em muitos outros tumores, a sua etiologia é desconhecida, contudo foram descobertas recentemente mutações no gene HRPT2/CDC73 que desempenham um papel fundamental na patogénese desta neoplasia. O CP é habitualmente uma doença esporádica mas pode ocorrer no contexto de síndromes genéticos e em doentes com hiperparatiroidismo secundário. O seu diagnóstico é um desafio, tanto clinica como histologicamente devido à ausência de características que permitam distinguir precocemente doença benigna de maligna. O tratamento com melhor potencial curativo é a resseção cirúrgica em bloco do tumor primário, com margens livres de doença pelo que o seu sucesso depende da suspeição pré ou intra-operatória do carcinoma. O CP tem um curso clínico prolongado com múltiplas recorrências, a maioria das quais ocorrem localmente, pelo que os doentes devem ser monitorizados para o resto da vida. Dado o valor limitado das terapias adjuvantes, o tratamento recomendado nos casos de recorrência e metástases é sempre que possível a resseção cirúrgica.

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Biografias Autor

Ana Luísa Castro Barbosa, Faculdade de Medicina da Universidade do Porto

Aluna do 6º ano de Medicina da Faculdade de Medicina da Universidade do Porto

João Capela Costa, Unidade de Cirurgia Endócrina e Cervical do Serviço de Cirurgia Geral do Hospital São João

MD MSc, Assistente Hospitalar Graduado da Unidade de Cirurgia Endócrina e Cervical do Serviço de Cirurgia Geral do Hospital São João, Porto, Portugal; Mestre em Medicina Molecular pela Faculdade de Medicina do Porto

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Publicado
2018-09-08
Como Citar
BARBOSA, Ana Luísa Castro; COSTA, João Capela. Carcinoma da Paratiróide. Revista Portuguesa de Cirurgia, [S.l.], n. 44, p. 25 - 36, set. 2018. ISSN 2183-1165. Disponível em: <https://revista.spcir.com/index.php/spcir/article/view/631>. Acesso em: 21 set. 2018.
Secção
Artigos de Revisão