IMPACT OF VISCERAL OBESITY ON OUTCOMES OF PERIAMPULLARY CANCER SURGERY

Maria Valentim; Patrícia Silva; Ana Pereira; Sónia Vilaça; Catarina Costa; Sandra F. Martins

doi:10.34635/rpc.942

Maria Valentim School of Medicine, University of Minho, Portugal http://orcid.org/0000-0002-8314-7520
Patrícia Silva General Surgery resident, Hospital de Braga, Portugal http://orcid.org/0000-0001-8523-2924
Ana Pereira General Surgery resident, Hospital de Braga, Portugal
Sónia Vilaça Hepatobiliary Graduated Assistant, Clinical Director of Hospital Lusíadas Braga, Portugal http://orcid.org/0000-0002-0368-2946
Catarina Costa Imagiology Department, Braga Hospital, Braga, Portugal http://orcid.org/0000-0003-0606-8930
Sandra F. Martins Coloproctology Unit, Department of General Surgery, Hospital de Braga, Portugal; Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal http://orcid.org/0000-0002-3526-3199

Abstract

Periampullary cancers are located up to a maximum distance of 2 cm from the duodenal papilla, with pancreatic cancer being the most common. Despite advances in surgical technique, survival rates remain low, making it essential to identify prognostic factors. Visceral obesity has been identified as a risk factor for cancer development, but its influence on the morbidity and mortality of operated patients remains controversial. This study aims to identify an association between the presence of preoperative visceral obesity and an increased risk of postoperative morbimortality in patients with periampullary cancers at Hospital de Braga. The sample includes 44 patients with periampullary cancers who underwent surgery with a curative intention between January/2011 and April/2018. The area of visceral fat was measured using the ImageJ software. Statistical analysis was performed using the SPSS software version 25. Visceral fat was not implicated in longer hospital stay or postoperative complications. The survival analysis showed no differences in disease-free survival at 1 year (p = 0.121) and 5 years (p = 0.222) or in overall survival at 1 year (p = 0.163) and 5 years (p = 0.053) between groups. Our data suggest that preoperative visceral obesity is not a risk factor for greater postoperative morbidity and mortality in individuals with periampullary cancers. Despite the reduced sample, this study evaluates visceral obesity in four types of tumors with many similar characteristics. Additional studies with larger samples are needed to confirm our observations.

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