IMPACT OF VISCERAL OBESITY ON OUTCOMES OF PERIAMPULLARY CANCER SURGERY

Maria Valentim; Patrícia Silva; Ana Pereira; Sónia Vilaça; Catarina Costa; Sandra F. Martins

doi:10.34635/rpc.942

Maria Valentim School of Medicine, University of Minho, Portugal http://orcid.org/0000-0002-8314-7520
Patrícia Silva General Surgery resident, Hospital de Braga, Portugal http://orcid.org/0000-0001-8523-2924
Ana Pereira General Surgery resident, Hospital de Braga, Portugal
Sónia Vilaça Hepatobiliary Graduated Assistant, Clinical Director of Hospital Lusíadas Braga, Portugal http://orcid.org/0000-0002-0368-2946
Catarina Costa Imagiology Department, Braga Hospital, Braga, Portugal http://orcid.org/0000-0003-0606-8930
Sandra F. Martins Coloproctology Unit, Department of General Surgery, Hospital de Braga, Portugal; Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal http://orcid.org/0000-0002-3526-3199

Resumo

Os tumores periampulares estão localizados a uma distância máxima de 2 cm da papila duodenal, sendo a neoplasia mais comum do pâncreas. Apesar dos avanços da técnica cirúrgica, as taxas de sobrevivência permanecem baixas, sendo fundamental a identificação de fatores determinantes do prognóstico. A obesidade visceral tem sido identificada como fator de risco para o desenvolvimento do cancro, mas a sua influência na morbimortalidade pós-operatória permanece controversa. Este estudo teve como objetivo explorar a associação entre a presença de obesidade visceral pré-operatória e o risco de morbimortalidade pós-operatória em indivíduos com cancro periampular no Hospital de Braga. A amostra é constituída por 44 indivíduos com cancro periampular, submetidos a cirurgia com intenção curativa, entre janeiro de 2011 e abril de 2018. A área de gordura visceral foi medida com recurso ao software ImageJ. A análise estatística foi realizada com o software SPSS versão 25. A gordura visceral não se associou ao maior tempo de internamento ou complicações pós-operatórias. A análise de sobrevivência não revelou diferenças no tempo livre de doença a 1 ano (p = 0,121) ou a 5 anos (p = 0,222), nem na sobrevida global a 1 ano (p = 0,163) ou a 5 anos (p = 0,053) entre os grupos. Os dados sugerem que a obesidade visceral pré-operatória não é fator de risco para maior morbimortalidade pós-operatória em indivíduos com cancro periampular. Apesar da amostra reduzida, este estudo avalia a obesidade visceral em quatro tipos de tumores com muitas características semelhantes. Estudos adicionais com amostras maiores são necessários para confirmar as nossas observações.

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IMPACTO DA GORDURA VISCERAL NO PROGNÓSTICO DA CIRURGIA DO CANCRO PERI-AMPOLAR

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