GIANT PHYLLODES TUMORS (BENIGN AND MALIGN VARIANT): CLINICAL CHANGES, SURGICAL TREATMENT AND AMBULATORY FOLLOW-UP – CASE REPORTS
DOI:
https://doi.org/10.34635/rpc.892Keywords:
Phyllodes Tumor, Breast Neoplasms, MastectomyAbstract
Phyloid Tumors are rare fibroepithelial tumors of the breast, representing less than 1% of all breast neoplasms, affecting women in the age group with the highest incidence between 40 and 50 years. With a variable biological behavior, the spectrum of benign presentation is confused with cellular fibroadenoma and, not the other extreme, the malignant presents similarities with other malignant neoplasms of the breast. Indicate, appear as a palpable, smooth, multinodular, firm, mobile and painless tumor, with abnormal mammographic and ultrasound findings. Tumor growth is usually rapid, with no correlation with increased risk of malignancy. The diagnosis is confirmed by histopathological evaluation. The treatment is eminently surgical, with excision with free margins and even mastectomy, a tumor-dependent extension being indicated. The presence of margins is important, since this contributes to the reduction of local recurrences, very common in this type of tumor. Adjuvant radiotherapy is controversial in the literature, but it appears to reduce recurrence without changing mortality. This article requires 02 cases of Phyloid Tumor, a benign and malignant variant, with which we aim to emphasize the importance of differential diagnosis and adequate surgical treatment, especially less postoperative morbidity.
Downloads
References
2. Reinfuss M, Mituś J, Duda K, et al. The treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases. Cancer 1996; 77:910.
3. Calhoun K, Allison KH, Kim JN, et al.. Phyllodes tumors. In: Diseases of the breast, Harris J, Lippman ME, Morrow M, Osborne KC (Eds), Lippincott Williams and Wilkins, 2014.
4. Tavassoli FA, Devilee P. and genetics of tumours of the breast and female genital organs. In: World Health Organization Classification of Tumours, IARC Press, Lyons 2003. p.99.
5. Strode M, Khoury T, Mangieri C, Takabe K. Update on the diagnosis and management of malignant phyllodes tumors of the breast. The Breast [Internet]. 2017 Jun;33:91–6.Available from: https://linkinghub.elsevier.com/retrie ve/pii/S0960977617300462
6. Karim RZ, Gerega SK, Yang YH, et al. Phyllodes tumours of the breast: a clinicopathological analysis of 65 cases from a single institution. Breast 2009; 18:165.
7. Zhou Z-R, Wang C-C, Yang Z-Z, Yu X-L, Guo X-M. Phyllodes tumors of the breast: diagnosis, treatment and prognostic factors related to recurrence. J Thorac Dis [Internet]. 2016 Nov;8(11):3361–8. Available from: http://jtd.amegroups.com/article/view/10314/9276
8. Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, et al. Phyllodes tumours of the breast: A consensus review. Histopathology. 2016;68(1):5–21.
9. Zhang Y, Kleer CG. Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates. Arch Pathol Lab Med [Internet]. 2016 Jul 1;140(7):665–71. Available from: http://meridian.allenpress.com/aplm/article/140/7/665/65332/Phyllodes-Tumor-of-the-Breast-Histopathologic
10. Ogunbiyi S, Perry A, Jakate K, Simpson J, George R. Phyllodes tumour of the breast and margins: How much is enough? Can J Surg. 2019;62(1):E19–21.
11. Oprić S, Oprić D, Gugić D, Granić M. Phyllodes tumors and fibroadenoma common beginning and different ending. [Internet]. Vol. 36, Collegium antropologicum. 2012. p. 235–41. Available from: http://www.ncbi.nlm.nih.gov/pubme d/22816226
12. Toussaint A, Piaget-Rossel R, Stormacq C et al. Width of margins in phyllodes tumors of the breast the controversy drags on? – a systematic review and meta-analysis. Breast Cancer Res Treat. 2021 Jan:185(1):21-37
13. Wei Y, Yu Y, Ji Y, Zhong Y, Min N, Hu H, Guan Q, Li X. Surgical management in phyllodes tumors of the breast: a systematic review and meta-analysis. Gland Surg. 2022 Mar;11(3):513-523.
Downloads
Published
Issue
Section
License
Para permitir ao editor a disseminação do trabalho do(s) autor(es) na sua máxima extensão, o(s) autor(es) deverá(ão) assinar uma Declaração de Cedência dos Direitos de Propriedade (Copyright). O acordo de transferência, (Transfer Agreement), transfere a propriedade do artigo do(s) autor(es) para a Sociedade Portuguesa de Cirurgia.
Se o artigo contiver extractos (incluindo ilustrações) de, ou for baseado no todo ou em parte em outros trabalhos com copyright (incluindo, para evitar dúvidas, material de fontes online ou de intranet), o(s) autor(es) tem(êm) de obter, dos proprietários dos respectivos copyrights, autorização escrita para reprodução desses extractos do(s) artigo(s) em todos os territórios e edições e em todos os meios de expressão e línguas. Todas os formulários de autorização devem ser fornecidos aos editores quando da entrega do artigo.