Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma

  • Ana Margarida Saraiva Santos Mosca Faculdade de Medicina da Unversidade do Porto Hospital de Braga
  • Laura Elisabete Barbosa Assistente Graduada de Cirurgia Geral

Abstract

Peritoneal carcinomatosis is an advanced stage of colorectal cancer, with poor prognosis, that has been regarded as an untreatable condition, suitable only for palliative treatment. Over the last decades new treatment options have emerged; cytoreductive surgery in combination with intraperitoneal chemotherapy has increasingly gain acceptance as a treatment for patients with colorectal peritoneal carcinomatosis. Recent clinical studies have suggested that this new approach could result in long-term survival in selected patients. The emerging trend is to regard peritoneal carcinomatosis as a regional metastatic disease, suitable to locoregional treatment. However a successful outcome depends on an appropriate selection of patients: patients with limited peritoneal disease, where complete cytoreduction is achieved have a greater benefit with this new therapeutic strategy. This review sumarizes indications, technical aspects, limitations, outcomes and challenges of this new approach in the treatment of colorectal peritoneal carcinomatosis.

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Author Biographies

Ana Margarida Saraiva Santos Mosca, Faculdade de Medicina da Unversidade do Porto Hospital de Braga

Mestrado Integrado de Medicina

Interna de formação específica de Medicina Interna

Hospital de Braga

Laura Elisabete Barbosa, Assistente Graduada de Cirurgia Geral
Assistente Graduada de Cirurgia Geral

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Published
2017-03-30
How to Cite
MOSCA, Ana Margarida Saraiva Santos; BARBOSA, Laura Elisabete. Therapeutic Approach of Peritoneal Carcinomatosis in patients with Colorectal Carcinoma. Revista Portuguesa de Cirurgia, [S.l.], n. 40, p. 35-50, mar. 2017. ISSN 2183-1165. Available at: <https://revista.spcir.com/index.php/spcir/article/view/443>. Date accessed: 23 sep. 2017.
Section
Review Article