Abordagem Terapêutica da Carcinomatose Peritoneal em doentes com Carcinoma Colorretal

  • Ana Margarida Saraiva Santos Mosca Faculdade de Medicina da Unversidade do Porto Hospital de Braga
  • Laura Elisabete Barbosa Hospital de São João

Resumo

A carcinomatose peritoneal (CP) é uma fase avançada da evolução do carcinoma colorretal que está associada a um mau prognóstico. A CP era compreendida como uma doença incurável, o tratamento consistia numa abordagem meramente paliativa. Durante as últimas décadas sugiram novas opções terapêuticas; a cirurgia citorredutora combinada com a quimioterapia intraperitoneal foi proposta como possibilidade terapêutica em doentes com carcinomatose peritoneal com origem no carcinoma colorretal (CCR). Estudos recentes defendem que esta nova abordagem pode promover um aumento da sobrevida em doentes selecionados. O conceito consiste em interpretar a CP como uma metastização regional da doença, suscetível a tratamento locorregional. Contudo, o resultado obtido depende da seleção adequada dos doentes submetidos a esta abordagem terapêutica: doentes com doença peritoneal limitada em que se verifica uma citorredução completa, apresentam benefício. Nesta revisão serão discutidas as indicações, os aspetos técnicos, as limitações, os resultados obtidos e os desafios desta nova abordagem terapêutica nos doentes com carcinomatose peritoneal com origem no CCR.

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Biografias Autor

Ana Margarida Saraiva Santos Mosca, Faculdade de Medicina da Unversidade do Porto Hospital de Braga

Mestrado Integrado de Medicina

Interna de formação específica de Medicina Interna

Hospital de Braga

Laura Elisabete Barbosa, Hospital de São João

 Assistente Graduada de Cirurgia Geral

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Publicado
2017-03-30
Como Citar
MOSCA, Ana Margarida Saraiva Santos; BARBOSA, Laura Elisabete. Abordagem Terapêutica da Carcinomatose Peritoneal em doentes com Carcinoma Colorretal. Revista Portuguesa de Cirurgia, [S.l.], n. 40, p. 35-50, mar. 2017. ISSN 2183-1165. Disponível em: <https://revista.spcir.com/index.php/spcir/article/view/443>. Acesso em: 23 nov. 2017.
Secção
Artigos de Revisão