Intraoperative radiotherapy and breast cancer
Abstract
Introduction: The delivery of radiotherapy in a single and high dose, during the surgery (IORT), is a matter of interest among medical community, particulary for early-stage invasive breast cancer.
Methods: We describe IORT, advantages and disadvantages and point out different techniques and publications going on, comparing IORT with external beam radiotherapy, to the whole breast.
Results: There are different systems and techniques of IORT calling for validation and for efficiency and efectiviness analisys. The ASTRO consensus guidelines for accelerated partial breast irradiation (APBI) might be considered for IORT.
Conclusions: IORT is an attractive radiotherapy modality, with an easy logistics and an interesting rational. It deserves, particulary for the newest technologies, additional peer-reviewed publications.
Keywords: breast cancer, intraoperative radiotherapy, accelerated partial breast irradiation.
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References
Calvo F, Biete A, et al. Oncologia radioterapica – Princípios, Métodos, Gestion e Pratica clínica. Ed. Arán 2010; 277-289.
Sperk E, Welzel G, et al. Late radiation toxicity after intraoperative (IORT) for breast cancer: results from the randomized phase III trial TARGIT A. Breast Cancer Res Treat 2012;139: 293-260.
Alvarado M, Mohan A, et al. Cost-Effectiveness Analisys of Intraoperative Radiation Therapy for Early-Stage Breast Cancer. Ann Surg Oncol 2013; 20:2873-2880.
Tuschy B, Berlit S, et al. Intraoperative Radiotherapy of Early Breast Cancer Using Low-Kilovoltage X-Rays – Reasons for Omission of Planned Intraoperative Irradiation. The Breast Journal 2013; 19: 329-328.
Mahesh M, Detorie N, Holt R, et al. Electronic Brachytherapy: Comparisons With External Beam and High Dose Rate 192Ir Brachytherapy. Journal American College Radiology 2008; 9: 221-223.
Tuschy B, Berlit S, et al. Clinical aspects of intraoperative radiotherapy in early breast cancer: short-term complications after IORT in women treated with low energy x-rays. Radiation Oncology 2013; 8: 99-98.
Vaidya J, Baum M, et al. Targeted intraoperative radiotherapy (TARGIT) yelds very low recurrence rates when given as a boost. Int. J. Radiation Oncology Biol. Phys 2006; 66: 1339-1338.
Lemansky C, Azria D , et al. Electrons for intraoperative radiotherapy in selected breast-cancer patients: late results of the Montpellier phase II trial. Radiation Oncology 2013; 8: 191-197.
Weltzel G, Boch A, et al. Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from randomized phase III trial. Radiation Oncology 2013; 8: 99-98.
