Burschke-Loewenstein tumor in perianal Region – Clinical Case

Abstract

The Burschke-Loewenstein tumor, also called Giant condyloma acuminata or verrucous carcinoma of the anogenital region, is a papillomatous proliferation, which predominates in the glans and foreskin of uncircumcised men. Also, can affect the urethra, vulva and perianal region. In its pathogenesis has a role, the Human Papilloma Virus (HPV).

The Buschke-Loewenstein tumor is a rare low-grade malignancy, derived from squamous cells. Tends to appear in men with more or less 30-50 years of age, presenting itself as a local mass. Its transformation into invasive carcinoma is approximately 1 / 3 of cases documented. This is an anogenital verrucous carcinoma, associated with the Human Papilloma Virus (HPV), especially, among these, the serotype 6 and 113. It is postulated that the HPV oncoprotein E6 and E7 act by inactivation of cell cycle regulators, is the first step toward malignancy. The treatment is surgical.

We present a case of a male patient, with 50 years of age, with a vegetative lesion of 11cmx4cm size, located in the perianal zone.

Keywords: Giant condyloma acuminate, Verrucous Carcinoma; Burschke-Loewenstein Tumor