Oncoplastic Management of a Giant Malignant Phyllodes Tumor: Nipple-Sparing Mastectomy with Immediate Breast Reconstruction

Authors

  • Miguel Jimenez-Yarza Hospital Regional Monterrey – Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Department of General Surgery, Nuevo León, Mexico https://orcid.org/0009-0000-6917-9940
  • Martín Sergio Rodríguez-Garza Hospital Regional Monterrey – Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Department of General Surgery, Nuevo León, Mexico
  • Rafael Delgado-Duarte Hospital General Zacatecas – Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Department of General Surgery, Zacatecas, Mexico
  • Manuel I. González-Geroniz Hospital Regional Monterrey – Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Department of Surgical Oncology, Nuevo León, Mexico
  • Marcelo Rodríguez-Ortiz Hospital Regional Monterrey – Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Department of Plastic and Reconstructive Surgery, Nuevo León, Mexico

DOI:

https://doi.org/10.34635/rpc.1122

Keywords:

Breast Neoplasms/surgery, Lymphatic Metastasis, Mastectomy, Segmental, Nipples/surgery, Phyllodes Tumor/surgery

Abstract

Malignant phyllodes tumors (MPTs) are rare, fast-growing breast neoplasms with a tendency to recur. We report the case of a 44-year-old woman with an 11 cm right breast mass diagnosed as a malignant phyllodes tumor. Due to the tumor’s size and location, she underwent a nipple-sparing subcutaneous mastectomy with immediate implant-based reconstruction. Histopathology confirmed malignancy with high stromal cellularity and a Ki-67 index of 20%; margins were negative. The postoperative course was uneventful aside from minor superficial areolar necrosis. No adjuvant therapy was required. This case illustrates the potential safety and feasibility of nipple-sparing mastectomy with reconstruction in select MPT patients. While wide excision with 1 cm margins remains standard, total mastectomy may be appropriate for large tumors. The case supports the value of individualized, multidisciplinary approaches that integrate oncologic safety with cosmetic outcomes.

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References

1. Simpson A, Li P, Dietz J. Diagnosis and management of phyllodes tumors of the breast. Ann Breast Surg. 2021;5:8. doi:10.21037/abs-20-99

2. Morioka E, Noguchi M, Noguchi M, et al. A case of recurrent malignant phyllodes tumor undergoing nipple-sparing mastectomy with immediate breast reconstruction. Surg Case Rep. 2020;6(1). doi:10.1186/s40792-020-01022-5

3. Lee ES. Recent Advances in Malignant Phyllodes Tumors of the Breast. J Breast Cancer. 2025;28. doi:10.4048/jbc.2024.0284

4. Lissidini G, Mulè A, Santoro A, et al. Malignant phyllodes tumor of the breast: a systematic review. Pathologica. 2022:1-10. doi:10.32074/1591-951x-754

5. Fede ÂB, Pereira Souza R, Doi M, et al. Malignant Phyllodes Tumor of the Breast: A Practice Review. Clin Pract. 2021;11(2):205-215. doi:10.3390/clinpract11020030

6. Abe H, Teramoto A, Takei Y, Tanaka Y, Yoneda G. Malignant phyllodes tumor of the breast with rapid progression: a case report. Surg Case Rep. 2020;6(1). doi:10.1186/s40792-020-00986-8

7. Abdelwahab KM, Elsaeed S, Hamdy O, Saleh MM, Hosam A. Nipple-sparing mastectomy and immediate breast reconstruction by prepectoral implant for the management of giant phyllodes tumors: A case series. Dis. 2024;43(1):231-236. doi:10.3233/bd-240011

8. Wei Y, Yu Y, Ji Y, et al. Surgical management in phyllodes tumors of the breast: a systematic review and meta-analysis. Gland Surg. 2022;11(3):513-523. doi:10.21037/gs-21-789

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Published

2025-10-21

Issue

Section

Clinical Case